Skip to main content
. Author manuscript; available in PMC: 2013 Feb 15.
Published in final edited form as: Arch Biochem Biophys. 2012 Jan 3;518(2):103–110. doi: 10.1016/j.abb.2011.12.023

Figure 1. HP1-binding motif in VHL.

Figure 1

(A) The PXVXL motif in human VHL and its alignment with other PXVXL-containing proteins. Bold residues in mCAF-1 are involved in hydrophobic interaction with HP1 chromo shadow domain. Proline 81 (asterisk) is mutated to serine in renal carcinoma-associated VHL P81S mutant.

(B) Sequence alignment of the PXVXL motif in VHL from different species.