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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Sep 25;1821(5):852–857. doi: 10.1016/j.bbalip.2011.09.010

Figure 2.

Figure 2

FATP’s role in disease based on gain and loss of function animal models and human studies. 1. Heart FATP1-TG causes lipotoxicity and affects diastolic function. 2. FATP1KO is protective against high-fat diet-induced insulin resistance by decreasing white adipose and muscle fat content. 3. Hepatic steatosis can be reversed by AAV-mediated FATP5 or FATP2 knock-down. 4. FATP4 loss alters fatty acid composition and disturbs the skin barrier function.