. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: IEEE Trans Med Imaging. 2011 Aug 8;31(2):153–163. doi: 10.1109/TMI.2011.2163944

TABLE III.

Image-based similarity measures after registration


Similarity Measure	Affine	FFD	SyN	CURT
RMS^*	24.9 ± 27.9^†	12.7 ± 13.9^†	15.4 ± 18.8^†	3.8 ± 5.1
NCC	0.59 ± 0.05^†	0.87 ± 0.04^†	0.82 ± 0.04^†	0.99 ± 0.01
NMI	1.03 ± 0.01^†	1.10 ± 0.02^†	1.08 ± 0.01^†	1.78 ± 0.02

Values are mean ± standard deviation for Root of Mean Squares (RMS), Normalized Cross Correlation (NCC), and Normalized Mutual Information (NMI) after registration over all 306 pairwise, directed registrations of the 18 IBSR images to one another. Smaller values are better for RMS, larger values are better for NCC and NMI.

^†

marks results significantly different from those obtained by CURT (p < 10⁻⁷ or smaller; two-sided paired t-tests).

Due to different intensity ranges among the original IBSR images, RMS values were computed from images that were globally normalized to identical intensity means and standard deviations.