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. Author manuscript; available in PMC: 2013 Feb 15.
Published in final edited form as: Anal Biochem. 2011 Dec 28;421(2):573–581. doi: 10.1016/j.ab.2011.12.032

Figure 4.

Figure 4

Effects of systemically administered kynurenine (100 mg/kg, i.p.; arrows) on the extracellular concentration of tryptophan (A) kynurenine (B) 3-HK (C) and QUIN (D) in the striatum of rats that had received intrastriatal injections of NMDA (“lesioned striatum”) or PBS (“contralateral striatum”) one week earlier (n = 6). Concentrations were not corrected for recovery from the microdialysis probe. With the exception of 3-HK (levels <2 nM, i.e. below the detection limit), baseline values for these animals are reported in Table 2. All metabolites were determined in the same samples. Data are the mean ± SEM. *p<0.05, ** p<0.01, ***p<0.001 vs. the contralateral striatum (two-way ANOVA followed by Bonferroni's post-hoc test).