Fig. 4.

% change of ICl_swell following long-term exposure to extracellular 0.1–10 μM curcumin. The % change in current was calculated from the current density-to-time relations represented in Fig. 3, i.e. after a 30 min exposure to an extracellular hypotonic solution in cells incubated 15–23 h in a complete medium containing 0.1, 0.5, 1.0, 5.0 and 10 μM curcumin respectively or 0.05% DMSO. 0.5–5.0 μM curcumin activated the current (∼64% with 1.0 μM curcumin), while 10 μM curcumin suppressed the current (∼40%).