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Responses of KCl (100 mmol/l)-precontracted rings of the rat thoracic aorta to acetylcholine (Ach, 10 µmol/l) before and after 20min treatment by xanthine (X, 0.1 mmol/l) and xanthine oxidase (XO, 0.1 IU/ml). Each bar represents the mean ± SEM of 5–7 experiments. Significant differences (at least p<0.05) were: (*) from the initial KCl-elevated tension, (▴) between the Ach-reached relaxation levels.
