Fig. 1.

Affinity of subtype-selective antimuscarinics for inhibiting carbachol-induced contraction of urinary bladder muscle strips in vitro from spinal injured patients. The shaded areas represent the affinity ranges of antimuscarinics [p-fluoro-hexahydrosiladifenadol (p-F-HHSiD), methoctramine (Methoc), and darifenacin (Darifen)] for the individual receptor subtypes reported in the literature (15, 29). Reported affinity ranges for the M₂ subtype is shaded with horizontal lines, and reported affinity for the M₃ subtype is shaded with vertical lines. Symbols refer to the affinities that were determined by Schild analysis of the bladder tissue obtained from the individual patient numbers indicated in Table 1.