Table 2. IC50 Data for Inhibition of Key Cytochrome P450 Isozymes.
| CYP450 isozyme | substrate/stock solution | conc (μM) | protein (mg/mL) | incubation (min) | IC50 data (μM) |
|---|---|---|---|---|---|
| CYP3A4 | testosterone (50 mM) | 100 | 0.3 | 30 | >200 |
| CYP3A4 | triazolam (50 mM) | 200 | 0.4 | 30 | >200 |
| CYP2D6 | dextromethorphan (50 mM) | 200 | 2.0 | 60 | >200 |
| CYP2C8 | amodiaquine (5 mM) | 200 | 0.4 | 30 | >65 |