. Author manuscript; available in PMC: 2013 Feb 20.

Published in final edited form as: Virology. 2011 Dec 29;423(2):175–186. doi: 10.1016/j.virol.2011.12.001

Table 4.

Effect of HIV-1 glycosylation on DC-SIGN transfer

Envelope	Genotype	Post-DC-SIGN binding method ^a IC₅₀ (nM)			Pre-DC-SIGN binding method IC₅₀ (nM)
Envelope	Genotype	GRFT	CV-N	SVN	GRFT	CV-N	SVN
CAAN5342.A2	^b WT	5.1 ± 0.1	18.8 ± 1.7	115.0 ± 2.4	7.1 ± 0.4	24.2 ± 2.1	153.0 ± 9.7
	234N	> 50	> 50	> 500	> 50	> 50	> 500
	295N	1.5 ± 0.2	7.3 ± 0.1	66.8 ± 3.0	3.5 ± 0.3	13.4 ± 0.3	140.6 ± 9.0
CAP63.A9J	WT	35.0 ± 5.4	24.0 ± 5.6	411.3 ± 62.9	38.7 ± 5.2	33.7 ± 3.7	590.0 ± 82.4
	234N	> 50	> 50	> 500	> 50	> 50	> 500
	295N	7.9 ± 0.2	9.2 ± 0.1	228.3 ± 3.0	11.5 ± 0.7	18.2 ± 1.0	357.1 ± 47.3

The concentration needed to inhibit HIV-1 transfer by 50%.

Wild type.