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Activation of an RTK induces dimerization and downstream phosphorylation of non-receptor tyrosine kinases. Major signaling cascades include the RAS/RAF/MAPK pathway, MEK pathway, and the PI3kinase/AKT pathway.
(Adapted by permission from Macmillan Publishers Ltd: Nature Reviews Cancer, Zhu & Parada, Nature Reviews Cancer, 2002, 2: 616–626, copyright 2002.)
