Figure 7.

Effects of the E308A and Q270A mutations on apo-Wt EPAC1_149-318. (a) The compounded chemical shift profile of the apo-mutant relative to apo-Wt. (b) Fractional shift toward activation achieved by the mutation in the absence of cAMP, as in Fig. 3b. (c) Projection angle as in Fig. 3c.