Figure 4.

Sequential aggregation pathways are plotted through the free energy surface (dashed lines) versus number of aggregated residue pairs at T = 1. (A) Aggregation pathway for double parallel peptides as 4-2-3-5-6-7-1. (B) Aggregation pathway for double antiparallel peptides as 4-6-2-3-5-1-7. (C) Illustration of sequential aggregation pathways. (Dashed lines) Newly formed aggregated residue pairs; (solid lines) previously formed aggregated residue pairs.