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. 2011 Jan 11;2011:0211.
Ref (type) Population Outcome, Interventions Results and statistical analysis Effect size Favours
Ankle brachial pressure index

Systematic review
104 people with intermittent claudication or critical limb ischaemia and superficial femoral artery stenosis or occlusion
Data from 1 RCT
Mean improvement in ankle brachial index 6 months
0.25 with percutaneous transluminal angioplasty (PTA) plus stent
0.18 with PTA alone

Mean difference 0.07
95% CI 0.04 to 0.10
Results should be interpreted with caution as it was unclear in some of the RCTs how many people in the PTA alone arm went on to have "bailout" (secondary) stenting and whether or not they were subsequently included in the PTA plus stent arm for analysis, or excluded from the trial
Effect size not calculated PTA plus stent

Systematic review
291 people with intermittent claudication or critical limb ischaemia and superficial femoral artery stenosis or occlusion
3 RCTs in this analysis
Mean improvement in ankle brachial index 12 months
with PTA plus stent
with PTA alone
Absolute results not reported

Mean difference 0.07
95% CI 0.05 to 0.09
Results should be interpreted with caution because of statistical heterogeneity as one large RCT in the analysis reported much higher results for ankle brachial index in the PTA plus stent group than the other RCTs
Results should be interpreted with caution as it was unclear in some of the RCTs how many people in the PTA alone arm went on to have "bailout" (secondary) stenting and whether or not they were subsequently included in the PTA plus stent arm for analysis, or excluded from the trial
Effect size not calculated PTA plus stent

Systematic review
98 people with intermittent claudication or critical limb ischaemia and superficial femoral artery stenosis or occlusion
Data from 1 RCT
Mean improvement in ankle brachial index 24 months
0.26 with PTA plus stent
0.23 with PTA alone
Review commented that the type of antiplatelet medication varied between the included RCTs; clopidogrel was given in one large RCT

Mean difference +0.03
95% CI –0.04 to +0.10
Results should be interpreted with caution as it was unclear in some of the RCTs how many people in the PTA alone arm went on to have "bailout" (secondary) stenting and whether or not they were subsequently included in the PTA plus stent arm for analysis, or excluded from the trial
Not significant