Ref (type) | Population | Outcome, Interventions | Results and statistical analysis | Effect size | Favours |
Ankle brachial pressure index | |||||
Systematic review |
104 people with intermittent claudication or critical limb ischaemia and superficial femoral artery stenosis or occlusion Data from 1 RCT |
Mean improvement in ankle brachial index
6 months
0.25 with percutaneous transluminal angioplasty (PTA) plus stent 0.18 with PTA alone |
Mean difference 0.07 95% CI 0.04 to 0.10 Results should be interpreted with caution as it was unclear in some of the RCTs how many people in the PTA alone arm went on to have "bailout" (secondary) stenting and whether or not they were subsequently included in the PTA plus stent arm for analysis, or excluded from the trial |
Effect size not calculated | PTA plus stent |
Systematic review |
291 people with intermittent claudication or critical limb ischaemia and superficial femoral artery stenosis or occlusion 3 RCTs in this analysis |
Mean improvement in ankle brachial index
12 months
with PTA plus stent with PTA alone Absolute results not reported |
Mean difference 0.07 95% CI 0.05 to 0.09 Results should be interpreted with caution because of statistical heterogeneity as one large RCT in the analysis reported much higher results for ankle brachial index in the PTA plus stent group than the other RCTs Results should be interpreted with caution as it was unclear in some of the RCTs how many people in the PTA alone arm went on to have "bailout" (secondary) stenting and whether or not they were subsequently included in the PTA plus stent arm for analysis, or excluded from the trial |
Effect size not calculated | PTA plus stent |
Systematic review |
98 people with intermittent claudication or critical limb ischaemia and superficial femoral artery stenosis or occlusion Data from 1 RCT |
Mean improvement in ankle brachial index
24 months
0.26 with PTA plus stent 0.23 with PTA alone Review commented that the type of antiplatelet medication varied between the included RCTs; clopidogrel was given in one large RCT |
Mean difference +0.03 95% CI –0.04 to +0.10 Results should be interpreted with caution as it was unclear in some of the RCTs how many people in the PTA alone arm went on to have "bailout" (secondary) stenting and whether or not they were subsequently included in the PTA plus stent arm for analysis, or excluded from the trial |
Not significant |