| Ref (type) | Population | Outcome, Interventions | Results and statistical analysis | Effect size | Favours |
| Adverse effects | |||||
|
[37]
Systematic review |
525 people 7 RCTs in this analysis |
Adverse effects
41/315 (13%) with alpha2-adrenoceptor agonists 15/210 (7%) with methadone |
RR 2.13 95% CI 1.30 to 3.48 P = 0.0026 |
Moderate effect size | methadone |
|
[36]
Systematic review |
1907 people |
Blood pressure
with clonidine with methadone |
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