Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Heroin use
[46] RCT	60 people, all of whom had detoxification and oral naltrexone for 3 days pre-randomisation In review [43] Data from 1 RCT	Proportion of urine samples negative for heroin (missing samples were not considered positive) 73.5% with depot naltrexone 192 mg given at 1 and 5 weeks after detoxification 79.4% with depot naltrexone 384 mg given at 1 and 5 weeks after detoxification 74.2% with depot placebo given at 1 and 5 weeks after detoxification Absolute numbers not reported	P = 0.85 for difference among groups		Not significant
[45] RCT	66 people, all of whom had detoxification and naltrexone 50 mg daily for 1 week pre-randomisation Data from 1 RCT	Heroin use over 6 months with oral naltrexone 0.05 mg with oral naltrexone 0.5 mg with oral naltrexone 50 mg	P = 0.156		Not significant