Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
[45] RCT	66 people, all of whom had detoxification and naltrexone 50 mg daily for 1 week pre-randomisation Data from 1 RCT	Ratings of adverse effects (depression, increased erections, increased thirst, low energy, and tiredness) with oral naltrexone 0.05 mg with oral naltrexone 0.5 mg with oral naltrexone 50 mg Absolute results reported graphically	P = 0.98 for difference among groups		Not significant
[43] Systematic review	42 people Data from 1 RCT	Adverse effects 15/22 (68%) with high-dose naltrexone 13/20 (65%) with low-dose naltrexone	RR 1.05 95% CI 0.68 to 1.16 P = 0.83		Not significant