Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
[53] Systematic review	18 people Data from 1 RCT	Adverse effects 3/18 (17%) wounds with topical negative pressure No data with usual care	Significance not assessed
[53] Systematic review	24 people Data from 1 RCT	Pain with topical negative pressure with simple foam dressing	Significance not assessed
[55] RCT	60 people with venous or arteriovenous ulcers of at least 6 months' duration	Erysipelas 1 with topical negative pressure vacuum-assisted closure (VAC) 0 with control (conventional wound care techniques)	Reported as not significant P value not reported		Not significant
[55] RCT	60 people with venous or arteriovenous ulcers of at least 6 months' duration	Pain 3 with topical negative pressure VAC 1 with control (conventional wound care techniques)	P value not reported
[55] RCT	60 people with venous or arteriovenous ulcers of at least 6 months' duration	Wound infection 0 with topical negative pressure VAC 1 with control (conventional wound care techniques)	P value not reported
[55] RCT	60 people with venous or arteriovenous ulcers of at least 6 months' duration	Postoperative bleeding at donor site 0 with topical negative pressure VAC 2 with control (conventional wound care techniques)	P value not reported
[55] RCT	60 people with venous or arteriovenous ulcers of at least 6 months' duration	Non-healing ulcers 1 with topical negative pressure VAC 1 with control (conventional wound care techniques)	P value not reported
[55] RCT	60 people with venous or arteriovenous ulcers of at least 6 months' duration	Cutaneous damage secondary to treatment 7 with topical negative pressure VAC 2 with control (conventional wound care techniques)	P <0.05	Effect size not calculated	control