Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Healing
[66] Systematic review	452 people 3 RCTs in this analysis	Ulcer healing 2 months with flavonoids with compression plus placebo or compression alone Absolute results not reported	HR 1.38 95% CI 1.11 to 1.70 See further information on studies	Small effect size	flavonoids
[67] Systematic review	616 people 5 RCTs in this analysis	Proportion of ulcers healed 6 months 61% with daflon 500 mg 48% with control Absolute numbers not reported	RRR 32% 95% CI 3% to 70% P = 0.03 Significant heterogeneity P = 0.014	Effect size not calculated	daflon
[66] Systematic review	107 people Data from 1 RCT	Cure rates at 2 months 14/53 (26%) with flavonoids 6/52 (11%) with placebo	RR 2.29 95% CI 0.99 to 5.43		Not significant
[66] Systematic review	107 people Data from 1 RCT	Time to healing of ulcers <10 cm2 at 2 months with flavonoids with placebo Absolute results not reported	P = 0.037	Effect size not calculated	flavonoids
[66] Systematic review	202 people (previously unpublished) Data from 1 RCT	Cure rates 2 months 21/103 (20%) with flavonoids plus compression 25/99 (25%) with compression plus placebo	Significance not assessed
[66] Systematic review	140 people Data from 1 RCT	Cure rates at 6 months 33/71 (47%) with flavonoids 19/69 (28%) with compression alone	OR 2.3 95% CI 1.1 to 4.6	Small effect size	flavonoids
[66] Systematic review	150 people Data from 1 RCT	Cure rates at 2 months 10/71 (14%) with flavonoids 6/69 (9%) with compression alone	Significance not assessed
[66] Systematic review	124 people (previously unpublished) Data from 1 RCT	Proportion of people healing 2 months 25/62 (40%) with flavonoids plus compression 13/62 (21%) with compression alone	Significance not assessed