Ref (type) | Population | Outcome, Interventions | Results and statistical analysis | Effect size | Favours |
Healing | |||||
[68]
RCT |
235 people |
Cure rates
3 months
63/121 (52%) with adding sulodexide to compression 36/114 (32%) with placebo |
RR 1.65 95% CI 1.28 to 18.54 |
Small effect size | sulodexide |
[69]
RCT |
95 people |
Cure rates
at 2 months
30/52 (58%) with adding sulodexide to compression 15/43 (35%) with compression alone |
RR 1.65 95% CI 1.06 to 2.7 NNT for 3 months' treatment 4 95% CI 3 to 9 |
Small effect size | sulodexide |
[70]
RCT |
44 people |
Healing rates
7 weeks
16/23 (70%) with adding intramuscular and then oral sulodexide to a compression regimen 7/21 (35%) with control |
P <0.05 |
Effect size not calculated | sulodexide |
[71]
RCT |
114 people |
Healing
at 30 days
32/61 (52%) with oral sulodexide 17/53 (32%) with compression alone |
P <0.05 |
Effect size not calculated | sulodexide |