Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Healing
[68] RCT	235 people	Cure rates 3 months 63/121 (52%) with adding sulodexide to compression 36/114 (32%) with placebo	RR 1.65 95% CI 1.28 to 18.54	Small effect size	sulodexide
[69] RCT	95 people	Cure rates at 2 months 30/52 (58%) with adding sulodexide to compression 15/43 (35%) with compression alone	RR 1.65 95% CI 1.06 to 2.7 NNT for 3 months' treatment 4 95% CI 3 to 9	Small effect size	sulodexide
[70] RCT	44 people	Healing rates 7 weeks 16/23 (70%) with adding intramuscular and then oral sulodexide to a compression regimen 7/21 (35%) with control	P <0.05	Effect size not calculated	sulodexide
[71] RCT	114 people	Healing at 30 days 32/61 (52%) with oral sulodexide 17/53 (32%) with compression alone	P <0.05	Effect size not calculated	sulodexide