Ref (type) | Population | Outcome, Interventions | Results and statistical analysis | Effect size | Favours |
Duration of hospital stay | |||||
RCT |
271 people with acute cholecystitis |
Duration of hospital stay
3 days with laparoscopic cholecystectomy 7 days with open cholecystectomy |
P <0.0001 |
Effect size not calculated | laparoscopic cholecystectomy |
RCT |
63 people with acute cholecystitis |
Duration of hospital stay
4 days with laparoscopic cholecystectomy 14 days with open cholecystectomy |
P = 0.0063 |
Effect size not calculated | laparoscopic cholecystectomy |
RCT |
230 people with acute cholecystitis |
Duration of hospital stay
5.8 days with laparoscopic cholecystectomy 8.5 days with open cholecystectomy |
Significance not assessed |
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RCT |
70 people with acute calculous cholecystitis |
Duration of hospital stay
1–10 days (median 2 days) with laparoscopic cholecystectomy 1–8 days (median 2 days) with open cholecystectomy Absolute results reported graphically Mean duration of stay was significantly longer with open surgery, although median duration of stay was the same in each group |
P = 0.01 |
Effect size not calculated | laparoscopic cholecystectomy |
Analgesic use | |||||
RCT |
271 people with acute cholecystitis |
Mean use of analgesia
75 mg pethidine with laparoscopic cholecystectomy 175 mg pethidine with open cholecystectomy |
P <0.0001 |
Effect size not calculated | laparoscopic cholecystectomy |
Postoperative complications | |||||
RCT |
271 people with acute cholecystitis |
Postoperative complications
24/146 (16%) with laparoscopic cholecystectomy 25/97 (26%) with open cholecystectomy |
Reported as not significant P value not reported |
Not significant | |
RCT |
63 people with acute cholecystitis |
Incidence of major postoperative complications
0% with laparoscopic cholecystectomy 23% with open cholecystectomy Absolute results not reported See further information on studies for details of types of complication reported |
P = 0.0048 for overall complication rate (includes major and minor complication rates) |
Effect size not calculated | laparoscopic cholecystectomy |
RCT |
63 people with acute cholecystitis |
Incidence of minor postoperative complications
3% with laparoscopic cholecystectomy 19% with open cholecystectomy Absolute results not reported See further information on studies for details of types of complication reported |
P = 0.0048 for overall complication rate (includes major and minor complication rates) |
Effect size not calculated | laparoscopic cholecystectomy |
RCT |
230 people with acute cholecystitis |
Postoperative complications
6/109 (6%) with laparoscopic cholecystectomy 14/116 (12%) with open cholecystectomy Postoperative complications were defined as haemorrhage, pneumonia, thrombosis, bile duct stones, bile leakage, or wound infections |
Significance not assessed |
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RCT |
70 people with acute cholecystitis |
Postoperative complications
2/35 (6%) with laparoscopic cholecystectomy 3/35 (9%) with open cholecystectomy Postoperative complications included minor stroke, wound infection, and pneumonia |
P = 0.65 |
Not significant |