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. 2011 Jun 28;2011:1118.
Ref (type) Population Outcome, Interventions Results and statistical analysis Effect size Favours
Functional improvement
[20]
RCT
85 people with sciatica caused by herniated disc Roland Morris Disability Questionnaire score (mean change from baseline) 35 days
–5.3 with epidural corticosteroid injections (2 mL prednisolone acetate at 2-day intervals for a total of 3 injections)
–3.2 with placebo (2 mL isotonic saline injection)

ARR –2.1
95% CI –5.0 to +0.8
Not significant
[19]
Systematic review
228 people with unilateral sciatica, possibly caused by disc herniation
Data from 1 RCT
Oswestry Disability Index 3 weeks
with triamcinolone 80 mg plus 10 mL bupivacaine 0.25%
with 2 mL normal saline
Absolute results not reported

Reported as significant difference; see further information on studies
P value not reported
Effect size not calculated triamcinolone 80 mg plus 10 mL bupivacaine 0.25%
[19]
Systematic review
228 people with unilateral sciatica, possibly caused by disc herniation
Data from 1 RCT
Oswestry Disability Index 6 weeks
with triamcinolone 80 mg plus 10 mL bupivacaine 0.25%
with 2 mL normal saline
Absolute results not reported

Reported as no significant difference; see further information on studies
P value not reported
Not significant
[19]
Systematic review
158 people with sciatica due to herniated nucleus pulposus
Data from 1 RCT
Oswestry Disability Index 3 weeks
with methylprednisolone acetate (80 mg and 8 mL of isotonic saline)
with 1 mL isotonic saline
Absolute results not reported

Significance not assessed
[19]
Systematic review
158 people with sciatica due to herniated nucleus pulposus
Data from 1 RCT
Oswestry Disability Index 3 months
with methylprednisolone acetate (80 mg and 8 mL of isotonic saline)
with 1 mL isotonic saline
Absolute results not reported

Reported as not significant
No further data reported
Not significant
[19]
Systematic review
228 people with unilateral sciatica, possibly caused by disc herniation
Data from 1 RCT
Oswestry Disability Index 75% improvement in scores 52 weeks
32.5% with triamcinolone 80 mg plus 10 mL bupivacaine 0.25%
29.6% with 2 mL normal saline

Significance not assessed; see further information on studies
[21]
RCT
76 people with leg and back pain caused by herniated disc Mean change in Oswestry Disability Index 3 months
13.6 with methylprednisolone 40 mg plus local anaesthetic
3.8 with local anaesthetic alone

Significance not assessed