Ref (type) | Population | Outcome, Interventions | Results and statistical analysis | Effect size | Favours |
Functional improvement | |||||
[20]
RCT |
85 people with sciatica caused by herniated disc |
Roland Morris Disability Questionnaire score (mean change from baseline)
35 days
–5.3 with epidural corticosteroid injections (2 mL prednisolone acetate at 2-day intervals for a total of 3 injections) –3.2 with placebo (2 mL isotonic saline injection) |
ARR –2.1 95% CI –5.0 to +0.8 |
Not significant | |
[19]
Systematic review |
228 people with unilateral sciatica, possibly caused by disc herniation Data from 1 RCT |
Oswestry Disability Index
3 weeks
with triamcinolone 80 mg plus 10 mL bupivacaine 0.25% with 2 mL normal saline Absolute results not reported |
Reported as significant difference; see further information on studies P value not reported |
Effect size not calculated | triamcinolone 80 mg plus 10 mL bupivacaine 0.25% |
[19]
Systematic review |
228 people with unilateral sciatica, possibly caused by disc herniation Data from 1 RCT |
Oswestry Disability Index
6 weeks
with triamcinolone 80 mg plus 10 mL bupivacaine 0.25% with 2 mL normal saline Absolute results not reported |
Reported as no significant difference; see further information on studies P value not reported |
Not significant | |
[19]
Systematic review |
158 people with sciatica due to herniated nucleus pulposus Data from 1 RCT |
Oswestry Disability Index
3 weeks
with methylprednisolone acetate (80 mg and 8 mL of isotonic saline) with 1 mL isotonic saline Absolute results not reported |
Significance not assessed |
||
[19]
Systematic review |
158 people with sciatica due to herniated nucleus pulposus Data from 1 RCT |
Oswestry Disability Index
3 months
with methylprednisolone acetate (80 mg and 8 mL of isotonic saline) with 1 mL isotonic saline Absolute results not reported |
Reported as not significant No further data reported |
Not significant | |
[19]
Systematic review |
228 people with unilateral sciatica, possibly caused by disc herniation Data from 1 RCT |
Oswestry Disability Index 75% improvement in scores
52 weeks
32.5% with triamcinolone 80 mg plus 10 mL bupivacaine 0.25% 29.6% with 2 mL normal saline |
Significance not assessed; see further information on studies |
||
[21]
RCT |
76 people with leg and back pain caused by herniated disc |
Mean change in Oswestry Disability Index
3 months
13.6 with methylprednisolone 40 mg plus local anaesthetic 3.8 with local anaesthetic alone |
Significance not assessed |