Fig. 6.

Menin and FOXO1 interaction in vivo. A: C57/BLK6 mice subjected to 18-h fast followed by 4 h of feeding and 7 h of refeeding. Whole liver lysates from mice were subjected to IP with menin antibody and immunoblotted for FOXO1 and menin by Western blot analysis. B: plasma insulin levels of C57/BLK6 mice subjected to 18-h fast followed by 4 h of feeding and 7 h of refeeding were determined by radioimmunoassay, as described in experimental procedures. Data analyzed using 1-way ANOVA; Turkey post hoc test. ***P < 0.0001; **P < 0.0017.