Fig. 7.

Effect of hepatic menin on FOXO1 target genes. C57/BLK6/FVB(129S) mice hemizygous for multiple endocrine neoplasia type 1 (MEN1) in the liver were subjected to an 18-h fast, and livers were extracted and analyzed. Genes that are direct targets of FOXO1 and directly involved in hepatic glucose production shown to be differentially expressed in the liver-specific hemizygous mice (HETs) vs. wild type (WT) based on results from quantitative real-time PCR. A: menin mRNA is decreased in the HETs; *P < 0.0145. B: insulin receptor (InsR); *P < 0.0172. C: total Akt; *P < 0.0249. D: total FOXO1. E: IGFBP-1; **P < 0.0026. F: glucose-6-phosphatase (G-6-Pase); *P < 0.0030. G: PGC-1α; *P < 0.0054. H: PEPCK. I: glucokinase (GK).