Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Taste disturbance
RCT	653 adolescents (aged 12–17 years), 510 included in the intention-to-treat analysis In review	Taste disturbance 60/238 (25%) with sumatriptan 20 mg 4/245 (2%) with placebo 48/255 (19%) with sumatriptan 5 mg	Significance not assessed
RCT Crossover design	129 children, 94 included in the intention-to-treat analysis In review	Taste disturbance 26/90 (29%) attacks with sumatriptan 3/87 (3%) attacks with placebo	P <0.001 The results of the RCT should be interpreted with caution as it randomised children but assessed results in relation to number of attacks	Effect size not calculated	placebo
Adverse effects other than taste disturbance
RCT	653 adolescents (aged 12 to 17 years), 510 included in the intention-to-treat analysis In review	Adverse effects (other than taste disturbance) with sumatriptan 20 mg with placebo with sumatriptan 5 mg			Not significant
RCT Crossover design	129 children, 94 included in the intention-to-treat analysis In review	Adverse effects (other than taste disturbance) with sumatriptan with placebo	The results of the RCT should be interpreted with caution as it randomised children but assessed results in relation to number of attacks		Not significant