Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	88 women Data from 1 RCT	Proportion of women with hypertension 13% with prednisolone plus low-dose aspirin (100 mg/day) 5% with placebo Absolute numbers not reported	P = 0.05		Not significant
Systematic review	202 women, including 88 women with antiphospholipid syndrome Data from 1 RCT	Proportion of women with gestational diabetes 15/101 (15%) with prednisolone plus low-dose aspirin (100 mg/day) 5/101 (5%) with placebo	RR 3.0 95% CI 1.1 to 7.9	Moderate effect size	placebo
Systematic review	202 women, including 88 women with antiphospholipid syndrome Data from 1 RCT	Proportion of women who had a preterm birth 41/101 (41%) with prednisolone plus low-dose aspirin (100 mg/day) 7/101 (7%) with placebo	RR 5.9 95% CI 2.8 to 12.4	Large effect size	placebo
Systematic review	202 women, including 88 women with antiphospholipid syndrome Data from 1 RCT	Proportion of babies admitted to neonatal ICU 18/101 (18%) with prednisolone plus low-dose aspirin (100 mg/day) 2/101 (2%) with placebo	RR 9.0 95% CI 2.1 to 37.8	Large effect size	placebo