Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	972 people (predominantly children) 5 RCTs in this analysis	Adverse effects 4 weeks 90/487 (18%) with antihistamine plus decongestant 35/485 (7%) with placebo	RR 2.54 95% CI 1.76 to 3.67	Moderate effect size	Placebo
Systematic review	Infants and older children with otitis media with effusion (OME), age range not reported	Adverse effects with antihistamines with Absolute results not reported