Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Resolution of otitis media with effusion (OME)
Systematic review	313 children 6 RCTs in this analysis	Complete resolution 15 to 90 days 80/161 (50%) with mucolytics (carbocisteine or carbocisteine lysine, or both) 54/152 (36%) with placebo	OR 2.25 95% CI 0.97 to 5.22 For details on heterogeneity and generalisability of results, see further information on studies		Not significant