Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Health-related quality of life
[69] Systematic review	696 people with COPD 2 RCTs in this analysis	Mean change in Chronic Respiratory Disease Questionnaire (CRQ) 6 months with fluticasone plus salmeterol with fluticasone Absolute numbers not reported	WMD +2.34 95% CI –3.15 to +7.82 P = 0.4		Not significant
[69] Systematic review	3001 people with COPD 3 RCTs in this analysis	Mean change in St George’s Respiratory Questionnaire (SGRQ) 1 to 3 years with fluticasone plus salmeterol with fluticasone Absolute numbers not reported	WMD –1.3 95% CI –2.04 to –0.57 P <0.0005	Effect size not calculated	fluticasone plus salmeterol
[69] Systematic review	917 people with COPD 2 RCTs in this analysis	Mean change in SGRQ 12 months with budesonide plus formoterol with budesonide Absolute numbers not reported	WMD –3.26 95% CI –5.10 to –1.42 P = 0.0005	Effect size not calculated	budesonide plus formoterol