Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
[69] Systematic review	4795 people with COPD 5 RCTs in this analysis	Proportion of people reporting an adverse effect 6 months to 3 years 1993/2382 (83.7%) with fluticasone plus salmeterol 2038/2413 (84.5%) with fluticasone alone	OR 0.94 95% CI 0.80 to 1.10 P = 0.41		Not significant
[69] Systematic review	5033 people with COPD 5 RCTs in this analysis	Episodes of pneumonia 6 months to 3 years 224/2501 (9%) with long-acting beta2 agonist (LABA) plus corticosteroid 202/2532 (8%) with fluticasone alone	OR 1.13 95% CI 0.92 to 1.38 P = 0.23		Not significant