Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
COPD exacerbations
[70] Systematic review	12,297 people with COPD 14 RCTs in this analysis	Exacerbations requiring hospital admission or withdrawal 1 month to >12 months 757/6685 (11.3%) with corticosteroid plus long-acting beta2 agonist (LABA) 704/5612 (12.5%) with LABA	RR 0.91 95% CI 0.82 to 1.01 P value not reported; reported as not significant		Not significant
[70] Systematic review	9590 people with COPD 11 RCTs in this analysis	Exacerbations requiring systemic corticosteroids 1 month to >12 months 794/4532 (18%) with corticosteroid plus LABA 1015/5058 (20%) with LABA	RR 0.84 95% CI 0.74 to 0.96 P = 0.008	Small effect size	corticosteroid plus LABA