Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Quality of life
[45] Systematic review	467 people 2 RCTs in this analysis	Total improvement in the Chronic Respiratory Disease Questionnaire (CRQ) 12 weeks with ipratropium with salmeterol Absolute results not reported	WMD –0.58 95% CI –3.50 to +2.35 P = 0.7		Not significant