Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
[9] [10] [11] [12] RCT	3400 people aged 40 to 75 years	Cumulative serious complications over the first year after surgery 12 months after surgery 247/1700 (15%) with intracapsular extraction plus aphakic glasses 131/1700 (8%) with manual large-incision extracapsular extraction plus IOL	P <0.001	Effect size not calculated	manual large-incision extracapsular extraction plus IOL
[9] [10] [11] [12] RCT	3400 people aged 40 to 75 years	Clinical cystoid macular oedema 12 months after surgery 59/1401 (4%) with intracapsular extraction plus aphakic glasses 23/1474 (2%) with manual large-incision extracapsular extraction plus IOL	RR 2.7 95% CI 1.7 to 4.3 See also further information on studies	Moderate effect size	manual large-incision extracapsular extraction plus IOL