Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT	219 children, aged 1 to 6 years with otoscopically diagnosed AOM and receiving antibiotic treatment with cefaclor for 7 days	Adverse effects (including mild nausea, vomiting, or abdominal pain) 5/71 (7%) with ibuprofen 3/75 (4%) with placebo	Significance not assessed
RCT	219 children, aged 1 to 6 years with otoscopically diagnosed AOM and receiving antibiotic treatment with cefaclor for 7 days	Adverse effects (including mild nausea, vomiting, or abdominal pain) 3/73 (4.1%) with paracetamol 3/75 (4.0%) with placebo	Significance not assessed