Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	1518 patients aged 4 weeks to 18 years 5 RCTs in this analysis	Diarrhoea with cefixime with amoxicillin or ampicillin Absolute numbers not reported	ARI 8.4% 95% CI 3.8% to 13.1% NNH 12 95% CI 8 to 27	Effect size not calculated	amoxicillin or ampicillin
Systematic review	1366 patients aged 4 weeks to 18 years 3 RCTs in this analysis	Gastrointestinal adverse effects with amoxicillin–clavulanic acid (co-amoxiclav) with azithromycin Absolute numbers not reported	ARI 18% 95% CI 8% to 28% NNH 6 95% CI 4 to 13	Effect size not calculated	azithromycin
Systematic review	2766 children aged 6 months to 15 years 10 RCTs in this analysis	Adverse effects with amoxicillin or amoxicillin–clavulanic acid with macrolide antibiotics Absolute numbers not reported	RR 0.74 95% CI 0.60 to 0.90 P = 0.003	Small effect size	macrolide antibiotics