Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptoms of AOM
Systematic review	5093 children aged between 4 weeks and 15 years 16 RCTs in this analysis	Treatment failure 1 month or less 486/2376 (20%) with short-course antibiotics (<7 days) 475/2717 (17%) with longer-course antibiotics (8–10 days)	OR 1.34 95% CI 1.15 to 1.55 P = 0.0001	Small effect size	longer-course antibiotics
Systematic review	3932 children aged between 4 weeks and 15 years 11 RCTs in this analysis	Treatment failure 8 to 19 days 340/1892 (18%) with short-course antibiotics (<7 days) 293/2040 (14%) with longer-course antibiotics (8–10 days)	OR 1.37 95% CI 1.15 to 1.64 P = 0.0004	Small effect size	longer-course antibiotics
Systematic review	2475 children aged between 4 weeks and 15 years 9 RCTs in this analysis	Treatment failure 20 to 30 days 238/1141 (21%) with short-course antibiotics (<7 days) 271/1335 (20%) with longer-course antibiotics (8–10 days)	OR 1.16 95% CI 0.94 to 1.42		Not significant
Systematic review	2068 children aged between 4 weeks and 15 years 7 RCTs in this analysis	Treatment failure 3 months or less 391/973 (40%) with short-course antibiotics (<7 days) 399/1095 (36%) with longer-course antibiotics (8–10 days)	OR 1.18 95% CI 0.98 to 1.41		Not significant
Systematic review	570 children aged between 4 weeks and 2 years 5 RCTs in this analysis	Treatment failure 1 month or less 99/296 (33%) with short-course antibiotics (<7 days) 85/274 (31%) with longer-course antibiotics (8–10 days)	OR 1.09 95% CI 0.76 to 1.57		Not significant
Systematic review	1064 children aged between 2 years and 15 years 6 RCTs in this analysis	Treatment failure 1 month or less 74/530 (14%) with short-course antibiotics (<7 days) 86/534 (16%) with longer-course antibiotics (8–10 days)	OR 0.85 95% CI 0.60 to 1.21		Not significant