Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Recurrence
Systematic review	37,868 children aged 2 months Data from 1 RCT	Episodes per person-year with vaccination with control vaccine Absolute results not reported	Relative risk reduction (RRR) 6% 95% CI 4% to 8%	Effect size not calculated	pneumococcal vaccine
Systematic review	1662 children aged 2 months Data from 1 RCT	Episodes per person-year 1.16 with vaccination 1.24 with control vaccine	RRR +6% 95% CI –4% to +16%		Not significant
Systematic review	1666 children aged 2 months Data from 1 RCT	Episodes per person-year with vaccination with control vaccine Absolute results not reported	RRR –1% 95% CI –12% to +10%		Not significant
Systematic review	4968 children aged 6 weeks to 5 months Data from 1 RCT	Episodes per person-year 0.08 with vaccination 0.13 with control vaccine	RRR 34% 95% CI 21% to 44%	Effect size not calculated	pneumococcal vaccine
Systematic review	264 children aged 12 months to 35 months Data from 1 RCT	Episodes per person-year 0.66 with vaccination 0.79 with control vaccine	RRR +17% 95% CI –2% to +33%		Not significant
Systematic review	383 children aged 1 year to 7 years with recurrent AOM Data from 1 RCT	Episodes per person-year 1.1 with vaccination 0.83 with control vaccine	RRR –29% 95% CI –62% to –2%	Effect size not calculated	control vaccine
Systematic review	74 children aged 1 year to 7 years with recurrent AOM Data from 1 RCT	Episodes per person-year 0.78 with vaccination 0.67 with control vaccine	RRR –16% 95% CI –96% to +31%		Not significant
Systematic review	37,868 children aged 2 months Data from 1 RCT	Recurrent AOM with vaccination with control vaccine Absolute results not reported	RRR 9% 95% CI 4% to 14%	Effect size not calculated	pneumococcal vaccine
Systematic review	1662 children aged 2 months Data from 1 RCT	Recurrent AOM with vaccination with control vaccine Absolute results not reported	RRR +9% 95% CI –12% to +27%		Not significant
Systematic review	4968 children aged 6 weeks to 5 months Data from 1 RCT	Recurrent AOM with vaccination with control vaccine Absolute results not reported	RRR +56% 95% CI –2% to +81%		Not significant