Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Breast pain
RCT Crossover design	26 women with cyclical breast pain of at least 6 months' duration who had persistent symptoms after a 2-month observation period with no hormonal treatment	Pain scores with oral medroxyprogesterone acetate 20 mg tablets with placebo Absolute results reported graphically	Reported as not significant The overall withdrawal rate was 15%		Not significant
RCT Crossover design	32 women with breast pain of at least 2 months' duration who were able to keep an updated diary with VAS of pain for 1 month	Pain scores measured by VAS before crossover with progesterone 1% cream with placebo cream Absolute results not reported	Reported as not significant Insufficient details were provided about the analysis 7/32 (22%) women withdrew from the study		Not significant