Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Cardiovascular events
[103] RCT 3-armed trial	9794 people with MI, left ventricular ejection fraction (LVEF) <0.40, or clinical heart failure	Cardiovascular mortality or heart failure 1331/4885 (27.2%) with valsartan plus captopril 1335/4909 (27.2%) with captopril alone	HR 1.00 97.5% CI 0.92 to 1.09 P = 0.94		Not significant
[104] RCT 3-armed trial	17,078 people with vascular disease	Cardiovascular mortality, MI, stroke, or hospital admission for heart failure 1386/8502 (16.3%) with telmisartan plus ramipril 1412/8576 (16.5%) with ramipril alone	RR 0.99 95% CI 0.92 to 1.07		Not significant
[104] RCT 3-armed trial	17,078 people with vascular disease	Fatal and non-fatal MI 438/8502 (5.2%) with telmisartan plus ramipril 413/8576 (4.8%) with ramipril alone	RR 1.08 95% CI 0.94 to 1.23		Not significant
Adverse events
[103] RCT 3-armed trial	9794 people with MI, LVEF <0.40, or clinical heart failure	Withdrawal because of adverse effects 438/4862 (9%) with valsartan plus captopril 375/4879 (8%) with captopril alone	P <0.05	Effect size not calculated	captopril alone
[103] RCT 3-armed trial	9794 people with MI, LVEF <0.40, or clinical heart failure	Withdrawal because of hypotension 90/4862 (2%) with valsartan plus captopril 41/4879 (1%) with captopril alone	P <0.05	Effect size not calculated	captopril alone
[104] RCT 3-armed trial	17,118 people with vascular disease	Withdrawal because of hypotension 406/8502 (5%) with telmisartan plus ramipril 149/8576 (2%) with ramipril alone	P <0.001	Moderate effect size	ramipril alone
[103] RCT 3-armed trial	9794 people with MI, LVEF <0.40, or clinical heart failure	Withdrawal because of hyperkalaemia 12/4862 (0.2%) with valsartan plus captopril 4/4879 (0.1%) with captopril alone			Not significant
[104] RCT 3-armed trial	17,118 people with vascular disease	Hyperkalaemia (potassium >5.6 mmol/L) 480/8502 (6%) with telmisartan plus ramipril 283/8576 (3%) with ramipril alone	P <0.001	Moderate effect size	ramipril alone