Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
All-cause mortality
[113] RCT	988 people with New York Heart Association (NYHA) functional class I to IV heart failure and left ventricular ejection fraction (LVEF) >45% Subgroup analysis	Rate of mortality mean follow-up of 37 months with digoxin with placebo Absolute results not reported	HR 0.99 95% CI 0.76 to 1.28 P = 0.92		Not significant
Cardiovascular mortality
[113] RCT	988 people with NYHA functional class I to IV heart failure and LVEF >45% Subgroup analysis	Rate of cardiovascular mortality mean follow-up of 37 months with digoxin with placebo Absolute results not reported	HR 1.00 95% CI 0.73 to 1.36 P = 0.98		Not significant