Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
[113] RCT	988 people with New York Heart Association (NYHA) functional class I to IV heart failure and left ventricular ejection fraction (LVEF) >45% Subgroup analysis	Rate of digoxin toxicity 10% with digoxin 4% with placebo Absolute numbers not reported	P <0.001	Effect size not calculated	placebo
[113] RCT	988 people with NYHA functional class I to IV heart failure and LVEF >45% Subgroup analysis	Proportion of people admitted to hospital with unstable angina with digoxin with placebo Absolute results not reported	HR 1.37 95% CI 0.99 to 1.91 P = 0.06 Result was of borderline significance		Not significant