Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
All-cause mortality
[34] Systematic review	8260 people 7 RCTs in this analysis	Rate of all-cause mortality 903/4265 (21%) with angiotensin II receptor blocker (ARB) plus ACE inhibitor 901/3995 (23%) with ACE inhibitor alone	OR 0.97 95% CI 0.87 to 1.08		Not significant
[36] Systematic review	Number of people not clear 2 RCTs in this analysis Subgroup analysis	Rate of mortality with ARB plus ACE inhibitor (without beta-blockers) with ACE inhibitor alone Absolute results not reported	OR 0.93 95% CI 0.81 to 1.06		Not significant
[36] Systematic review	Number of people not clear 2 RCTs in this analysis Subgroup analysis	Rate of mortality with ARB plus ACE inhibitor (with beta-blockers) with ACE inhibitor alone Absolute results not reported	OR 1.08 95% CI 0.90 to 1.29 There was statistical heterogeneity between the RCTs (P <0.05)		Not significant
[35] Systematic review	7999 people 3 RCTs in this analysis	Rate of mortality 901/4119 (22%) with ARB plus ACE inhibitor 900/3980 (23%) with ACE inhibitor alone	RR 0.98 95% CI 0.84 to 1.15		Not significant
Mortality and morbidity
[36] Systematic review	7666 people 4 RCTs in this analysis	Rate of a composite outcome of mortality and morbidity with ARB plus ACE inhibitor (with or without beta-blockers) with ACE inhibitor alone Absolute results not reported	OR 0.89 95% CI 0.81 to 0.98	Small effect size	ARB plus ACE inhibitor
[36] Systematic review	Number of people not clear 2 RCTs in this analysis Subgroup analysis	Rate of a composite outcome of mortality and morbidity with ARB plus ACE inhibitor (without beta-blockers) with ACE inhibitor alone Absolute results not reported	OR 0.83 95% CI 0.73 to 0.94	Small effect size	ARB plus ACE inhibitor
[36] Systematic review	Number of people not clear 2 RCTs in this analysis Subgroup analysis	Rate of a composite outcome of mortality and morbidity with ARB plus ACE inhibitor (with beta-blockers) with ACE inhibitor alone Absolute results not reported	OR 0.94 95% CI 0.80 to 1.10 There was statistical heterogeneity between the RCTs (P <0.05)		Not significant