Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
All-cause mortality
[59] Systematic review	10,807 people 19 RCTs in this analysis	Rate of mortality 804/5565 (14%) with aldosterone receptor antagonists 994/5200 (19%) with control	RR 0.80 95% CI 0.74 to 0.87 The results of the review may not be generalisable to all people with heart failure (see further information on studies for more details)	Small effect size	aldosterone receptor antagonists
[59] Systematic review	3353 people with heart failure 15 RCTs in this analysis Subgroup analysis	Rate of mortality 303/1858 (16%) with aldosterone receptor antagonists 404/1495 (27%) with control	RR 0.75 95% CI 0.67 to 0.84 The results of the review may not be generalisable to all people with heart failure (see further information on studies for more details)	Small effect size	aldosterone receptor antagonists
[59] Systematic review	7412 people with heart failure after an MI 4 RCTs in this analysis Subgroup analysis	Rate of mortality 501/3707 (14%) with aldosterone receptor antagonists 590/3705 (16%) with control	RR 0.85 95% CI 0.76 to 0.95 The results of the review may not be generalisable to all people with heart failure (see further information on studies for more details)	Small effect size	aldosterone receptor antagonists