Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
All-cause mortality
[63] Systematic review	4525 people 8 RCTs in this analysis	Rate of mortality 3 to 24 months 436/2262 (19%) with amiodarone 507/2263 (22%) with placebo or conventional treatment	ARR 3.0% 95% CI 0.8% to 5.3% RR 0.86 95% CI 0.76 to 0.96	Small effect size	amiodarone
[64] Systematic review	6553 people 13 RCTs in this analysis	Rate of annual mortality mean follow-up of 16 months 11% with amiodarone 12% with placebo or conventional treatment Absolute numbers not reported	Fixed effects model OR 0.87 95% CI 0.78 to 0.99 Random effects model OR 0.85 95% CI 0.71 to 1.02 The effect of amiodarone was significantly greater in RCTs comparing amiodarone versus usual care than in placebo-controlled RCTs
[64] Systematic review	6553 people 13 RCTs in this analysis	Rate of arrhythmic death or sudden death mean follow-up of 16 months with amiodarone with placebo or conventional treatment Absolute results not reported	OR 0.71 95% CI 0.59 to 0.85 The effect of amiodarone was significantly greater in RCTs comparing amiodarone versus usual care than in placebo-controlled RCTs	Small effect size	amiodarone
[64] Systematic review	1452 people with heart failure 5 RCTs in this analysis Subgroup analysis	Rate of annual mortality mean follow-up of 16 months 20% with amiodarone 24% with placebo or conventional treatment Absolute numbers not reported	OR 0.83 95% CI 0.70 to 0.99 The effect of amiodarone was significantly greater in RCTs comparing amiodarone versus usual care than in placebo-controlled RCTs	Small effect size	amiodarone