Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Changes in ophthalmopathy
RCT 3-armed trial	114 people with hyperthyroidism caused by Graves' disease	Proportion of people with worsening ophthalmopathy 13/39 (33%) with radioiodine 4/38 (10%) with medical antithyroid treatment	Between-group P value not reported P = 0.02 for radioiodine v surgery or medical antithyroid treatment combined	Effect size not calculated	medical antithyroid treatment
RCT 3-armed trial	443 people with Graves' hyperthyroidism and mild or no ophthalmopathy	Proportion of people with worsening ophthalmopathy 2 to 6 months 23/150 (15%) with radioiodine 4/148 (3%) with thiamazole	P <0.001	Effect size not calculated	thiamazole
RCT	313 people with a recent diagnosis of Graves' hyperthyroidism	Proportion of people with thyroid-associated ophthalmopathy 18 months 63/163 (39%) with iodine-131 32/150 (21%) with methimazole 15 mg twice daily	P <0.001	Effect size not calculated	methimazole