Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Changes in ophthalmopathy
RCT 3-armed trial	150 people with Graves' disease Subgroup analysis	Proportion of people with improvement in Graves' ophthalmopathy 22/31 (71%) with total thyroidectomy 21/29 (72%) with bilateral subtotal thyroidectomy (total remnant <4 mL) 20/29 (69%) with unilateral total thyroidectomy plus contralateral subtotal thyroidectomy (remnant <4 mL)	P >0.05 among groups		Not significant
RCT 3-armed trial	150 people with Graves' disease Subgroup analysis	Proportion of people with documented improvement of eye symptoms 71% with total thyroidectomy 74% with bilateral subtotal thyroidectomy (total remnant <4 mL) 74% with unilateral total thyroidectomy plus contralateral subtotal thyroidectomy (remnant <4 mL) Absolute numbers not reported	P >0.05 among groups		Not significant
RCT 3-armed trial	150 people with Graves' disease Subgroup analysis	Reduction in Graves' opthalmopathy score (American Thyroid Association scale; 0 = best, 40 = worst) –2.0 with total thyroidectomy –2.5 with bilateral subtotal thyroidectomy (total remnant <4 mL) –2.0 with unilateral total thyroidectomy plus contralateral subtotal thyroidectomy (remnant <4 mL) Absolute numbers not reported	P >0.05 among groups		Not significant