Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Improvement in bulimia symptoms
RCT 3-armed trial	71 people In review	Bulimic symptoms with desipramine (mean 167 mg/day) with CBT-BN (16 weekly sessions with 2 follow-up sessions) Absolute results not reported	SMD –0.02 95% CI –0.72 to +0.68		Not significant
RCT 3-armed trial	171 people In review	Mean reduction in number of binges a week 3.6 with imipramine 200 mg to 300 mg daily 8.2 with group-based CBT-BN	Between group significance assessment not performed
Remission
Systematic review	People with bulimia nervosa Data from 1 RCT	Binge-eating non-remission rate 45/54 (83%) with imipramine 200 mg to 300 mg daily 17/34 (50%) with group-based CBT-BN	RR 1.67 95% CI 1.17 to 2.38	Small effect size	CBT-BN
Systematic review	People with bulimia nervosa Data from 1 RCT	Binge-eating non-remission rate 7/12 (58%) with desipramine (mean 167 mg/day) 10/23 (43%) with CBT-BN (16 weekly sessions with 2 follow-up sessions)	RR 1.34 95% CI 0.69 to 2.62		Not significant