Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT	265 eyes undergoing initial or repeat vitrectomy for rhegmatogenous retinal detachment (RRD) with severe proliferative vitreoretinopathy (PVR) In review	Keratopathy last follow-up examination (up to 36 months) 30% with silicone oil 33% with C3F8 Absolute numbers not reported	P = 0.70		Not significant
RCT	245 eyes undergoing initial or repeat vitrectomy for RRD with severe PVR Further report of reference	Elevated intraocular pressure (raised intraocular pressure to >25 mmHg on 2 or more consecutive visits) 6 months 9/120 (8%) eyes with silicone oil 2/121 (2%) eyes with C3F8	P <0.05	Effect size not calculated	C3F8
RCT	245 eyes undergoing initial or repeat vitrectomy for RRD with severe PVR Further report of reference	Chronic hypotony (intraocular pressure <5 mmHg on 2 or more consecutive or 3 visits) 6 months 21/120 (18%) eyes with silicone oil 37/121 (31%) eyes with C3F8	P <0.05	Effect size not calculated	silicone oil
RCT	245 eyes undergoing initial or repeat vitrectomy for RRD with severe PVR Further report of reference	Macular pucker 6 months 12% with silicone oil 19% with C3F8 Absolute numbers not reported	P = 0.15		Not significant