| GISTs arise from interstitial cells of Cajal (ICC), |
| KIT is essential for the development and function of hematopoietic cells, ICC, melanocytes, and germ cells. |
| KIT (also termed CD117) is structurally related to PDGFRA and encodes a 145-kDA RTK. |
| 95% of GIST tumors express KIT (or CD117). |
| KIT mutations are noted in approximately 85% of GIST. PDGFRA accounts for 5–10%, and remaining 10–15% have no mutations (WT). |
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