Fig. 1.

The effect of leptin replacement on free testosterone and SHBG in women with lipodystrophy. A, Free testosterone levels decrease significantly from 3.05 ± 0.6 to 1.7 ± 0.3 ng/ml after 1 yr of leptin replacement (P = 0.02). B, Seventy-four percent of the female patients with lipodystrophy experienced a decrease in free testosterone level at the end of 1 yr of leptin replacement, whereas only 17.5% of the patients had an increase and 8.5% remained stable. C, Serum SHBG was significantly increased by leptin from 14.5 ± 2 to 25 ± 3.5 nmol/liter. D, Eighty-three percent of patients had an increase in SHBG after 1 yr of leptin therapy.