Table 1.
Indices of insulin secretion and action according to categorization
| NFG/NGT | IFG/NGT | NFG/IGT | IFG/IGT | IFG/DM | Pa | |
|---|---|---|---|---|---|---|
| n | 36 | 18 | 36 | 57 | 18 | |
| Glucose0 (mmol/liter) | 5.22 ± 0.04 | 5.90 ± 0.06 | 5.22 ± 0.06 | 5.90 ± 0.04 | 6.20 ± 0.21 | <0.01 |
| Pb | <1.0 × 10−5 | 0.70 | <1.0 × 10−5 | <1.0 × 10−5 | ||
| Glucose120 (mmol/liter) | 6.83 ± 0.11 | 6.47 ± 0.17 | 8.98 ± 0.16 | 8.94 ± 0.12 | 13.12 ± 0.27 | <0.01 |
| Pb | 0.63 | <1.0 × 10−5 | <1.0 × 10−5 | <1.0 × 10−5 | ||
| % body fat | 38.3 ± 1.8 | 39.5 ± 2.3 | 40.3 ± 1.6 | 42.2 ± 1.2 | 42.7 ± 2.1 | >0.10 |
| BMI (kg/m2) | 25.9 ± 0.7 | 28.1 ± 0.8 | 25.3 ± 0.6 | 29.0 ± 0.6 | 27.4 ± 0.9 | <0.01 |
| Pb | 0.06 | 0.46 | 0.002 | 0.10 | ||
| Age (yr) | 63.9 ± 1.1 | 62.3 ± 1.9 | 67.1 ± 1.3 | 67.4 ± 0.9 | 69.0 ± 1.6 | <0.01 |
| Pb | 0.48 | 0.03 | 0.02 | 0.03 | ||
| Si (10−4 dl/kg · min per μU/ml) | 22.0 ± 2.5 | 17.8 ± 2.2 | 12.4 ± 1.1 | 8.9 ± 1.0 | 3.1 ± 0.7 | <0.01 |
| Pb | 0.31 | 3.6 × 10−4 | 3.9 × 10−7 | 3.0 × 10−5 | ||
| φ (10−9 min−1) | 54.9 ± 3.1 | 64.8 ± 7.1 | 48.0 ± 4.2 | 55.0 ± 3.0 | 41.6 ± 2.7 | <0.01 |
| Pb | 0.17 | 0.15 | 0.98 | 0.009 | ||
| DI (10−14 dl/kg/min−2 per pmol/liter) | 1807 ± 189 | 1874 ± 306 | 940 ± 113 | 681 ± 59 | 209 ± 45 | <0.01 |
| Pb | 0.82 | 7.6 × 10−5 | 3.4 × 10−9 | 3.4 × 10−6 |
Data represent mean ± sem.
a
P value calculated by ANOVA.
b
P value calculated by two-tailed t test in comparison with NFG/NGT.